Cryopreserved Fetal Liver Cells Immobilized in Macroporous Carriers Promote Liver Function Recovery After Injury With 2-Acetylaminefluorene

Abstract

The effect of cryopreserved fetal liver cells immobilized in macroporous alginate scaffolds on liver injury degree in rats with modelof liver failure developed by administration of 2-acetylaminofluorene with subsequent partial hepatectomy. It was shown thatimmobilized fetal liver cells accelerated recovery of spesific hepatic indices: serum albumin, total bilirubin content, aminotransferaseactivity. The results of this work indicate the positive effect of fetal liver cells seeded in macroporous scaffolds on course of liverfailure and argue the availability of this approach for liver failure treatment.