THE EFFECT OF NEW PENTAMETHINE CYA NINE DYES ON LEVEL OF hMSC NUCLEAR DNA DAMAGE IN VITRO

Abstract

We have studied the series of pentamethine cyanine dyes derived from benzothiazole heterocycles with different substituents emitted on near-infrared region. Incubation of human skin-derived mesenchymal stem cells with cyanine dyes 1871SI and 1749SI (1µM) leads to an increase in the induction of apoptosis in cells, increase in level of apoptosis-induced nuclear DNA fragmentation