Comparative Evaluation of Biological Activity of Fraction Below 5 kDa from Cattle Cord Blood After Low-Temperature Storage (at –80°C) or Lyophilization to Treat Burn Wounds in Rats

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dc.contributor.advisor
dc.contributor.authorGulevskyy, A.K.
dc.contributor.authorMoiseyeva, N.N.
dc.contributor.authorGorina, O.L.
dc.contributor.authorNikolchenko, A.Yu.
dc.contributor.authorSchenyavsky, I.I.
dc.date.accessioned2022-09-06T09:35:44Z
dc.date.available2022-09-06T09:35:44Z
dc.date.issued2020
dc.descriptionGulevskyy, O., Moiseyeva, N., Gorina, O., Nikolchenko, A., & Schenyavsky, I. (2020). Comparative Evaluation of Biological Activity of Fraction Below 5 kDa from Cattle Cord Blood After Low-Temperature Storage (at -80°C) or Lyophilization to Treat Burn Wounds in Rats. Problems of Cryobiology and Cryomedicine, 30(1), 47–57.
dc.description.abstractBiological activity of the low molecular weight (down to 5 kDa) fraction from cattle cord blood after storage in lyophilized state at 4°C and -80°C in the form of solution in a model of thermal burn of rats' skin was investigated. Actovegin with a pronounced wound healing activity was used as a comparator drug. The storage of low molecular weight fraction for 3 months under the chosen conditions was found not to reduce its biological activity. Introduced and lyophilized cord blood fraction to experimental animals after simulation of thermal skin burns contributed to a reduced burn wound area, normalization of leukocyte content and phagocytic activity of neutrophils in peripheral blood. The findings enable considering the lyophilization of the low molecular weight fraction followed by storage at 4°C as sensibly more expedient option of storing and transporting the biologically active substance.uk_UA
dc.description.provenanceSubmitted by Горіна Ольга Леонідівна (ogorina2603@gmail.com) on 2022-09-06T09:35:44Z No. of bitstreams: 1 1601-Article Text-3253-1-10-20200328.pdf: 580062 bytes, checksum: 5c7f112ff7b45fc11fbf72914c5c3350 (MD5)en
dc.description.provenanceMade available in DSpace on 2022-09-06T09:35:44Z (GMT). No. of bitstreams: 1 1601-Article Text-3253-1-10-20200328.pdf: 580062 bytes, checksum: 5c7f112ff7b45fc11fbf72914c5c3350 (MD5) Previous issue date: 2020en
dc.identifier.citationGulevskyy, O., Moiseyeva, N., Gorina, O., Nikolchenko, A., & Schenyavsky, I. (2020). Comparative Evaluation of Biological Activity of Fraction Below 5 kDa from Cattle Cord Blood After Low-Temperature Storage (at -80°C) or Lyophilization to Treat Burn Wounds in Rats. Problems of Cryobiology and Cryomedicine, 30(1), 47–57.uk_UA
dc.identifier.urihttps://doi.org/10.15407/cryo30.01.047
dc.identifier.urihttp://cryo.net.ua/xmlui/handle/123456789/448
dc.language.isoenuk_UA
dc.publisherProblems of Cryobiology and Cryomedicineuk_UA
dc.relation.ispartofseries30(1);47-57
dc.subjectlow molecular weight fractionuk_UA
dc.subjectcord blooduk_UA
dc.subjectlow temperature storageuk_UA
dc.subjectlyophilizationuk_UA
dc.subjectbiological activityuk_UA
dc.subjectburnuk_UA
dc.titleComparative Evaluation of Biological Activity of Fraction Below 5 kDa from Cattle Cord Blood After Low-Temperature Storage (at –80°C) or Lyophilization to Treat Burn Wounds in Ratsuk_UA
dc.typeArticleuk_UA

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